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Sr. No.	Parameters	Soft Bags	Plastic Bottle on BFS	Remarks
1.	Aseptic packaging (product is aseptic even before terminal sterilization)	No	Yes	Microbiologically, BFS bottles offer excellent quality
2.	Approx. Estimated Cost (referred to cost of 500 ml container, India)	More than 0,2 Euro/bag	0,08 Euro/bottle	-
3.	Collapsibility (External air does not get introduced in container while dispensing)	Excellent collapsibility	Good collapsibility	Collapsible containers are preferred in hospitals
4.	Particles in solution	Within allowable limit in pharmacopoeia	Much less than allowable limit in pharmacopoeia	It is preferred that solution is free of particles
5.	Availability of packaging material (granule or plastic film)	Film is available only in USA, Japan, Germany, France	Granules are easily available in many countries. Brazil, UAE, India, USA, China, Japan, Taiwan, Iran, Russia, Zagreb, Europe	Plastic Granules are most easily available even during wars and embargos
6.	Pyrogenic load	Less than limit in pharmacopoeia	Much less than limit in pharmacopoeia	-
7.	Stability for most common IV fluids	2 years	5 years	-
8.	Influence of quality of packaging material	Bag making machines are very sensitive and work with specific film	BFS can tolerate variations in physical characteristics of plastic material	-

Sr. No.

Parameters

Soft Bags

Plastic Bottle on BFS

Remarks

Aseptic packaging (product is aseptic even before terminal sterilization)

Yes

Microbiologically, BFS bottles offer excellent quality

Approx. Estimated Cost (referred to cost of 500 ml container, India)

More than 0,2 Euro/bag

0,08 Euro/bottle

Collapsibility (External air does not get introduced in container while dispensing)

Excellent collapsibility

Good collapsibility

Collapsible containers are preferred in hospitals

Particles in solution

Within allowable limit in pharmacopoeia

Much less than allowable limit in pharmacopoeia

It is preferred that solution is free of particles

Availability of packaging material (granule or plastic film)

Film is available only in USA, Japan, Germany, France

Granules are easily available in many countries. Brazil, UAE, India, USA, China, Japan, Taiwan, Iran, Russia, Zagreb, Europe

Plastic Granules are most easily available even during wars and embargos

Pyrogenic load

Less than limit in pharmacopoeia

Much less than limit in pharmacopoeia

Stability for most common IV fluids

2 years

5 years

Influence of quality of packaging material

Bag making machines are very sensitive and work with specific film

BFS can tolerate variations in physical characteristics of plastic material